Prof. Dr. Akdemir’in temel araştırma ilgi alanı yeni ilaç aday bileşiklerinin keşfi ve tasarımıdır. Bu amaçla moleküler modelleme ve moleküler farmakoloji çalışmalarını bir arada yürütmektedir. Doktora derecesini aldıktan sonra bir ilaç geliştirme şirketinde hesaplamalı kimyager olarak göreve başladı. 2011 yılında Bezmialem Vakıf Üniversitesi Eczacılık Fakültesi Farmakoloji anabilim dalında yardımcı doçent kadrosuna atandı. Eczacılık Fakültesi müfredatını oluşturdu ve “İlaç Keşfi ve Geliştirme” Yüksek Lisans ve Doktora programlarının yanı sıra Bilgisayar Destekli İlaç Tasarımı araştırma laboratuvarının kurucusudur. Kurumsal Erasmus Koordinatörü olarak Erasmus ve Erasmus+ charter’larını almıştır. 2013 yılında Eczacılık Fakültesi Dekan Yardımcılığı görevini üstlenmiştir. 2023 yılında İstinye Üniversitesi Eczacılık Fakültesi’nde akademik göreve başlamış ve Temmuz 2023’te Eczacılık Fakültesi Dekanlığı görevine atanmıştır. Prof. Dr. Akdemir’in 64 adet araştırma makalesi ve 5 kitap bölümü bulunmakta olup H-indeksi 22’dir.
Araştırma Alanları
- Bilgisayar Destekli İlaç Keşif ve Tasarım
- Moleküler Modelleme
- Moleküer Farmakoloji
- in silico ADMET hesaplama
Çalışma Alanları
- Sağlık Bilimleri Temel Alanı
- Farmakoloji
- Thiosemicarbazone-benzene Sulfonamide Derivatives as Human Carbonic Anhydrases Inhibitors: Synthesis, Characterization, and In silico Studies, 2024
- Dithiocarbamates and dithiocarbonates containing 6-nitrosaccharin scaffold: Synthesis, antimycobacterial activity and in silico target prediction using ensemble docking-based reverse virtual screening, 2023
- Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies, 2022
- Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII, 2022
- The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies, 2022
- Synthesis, anti‐TB activities, and molecular docking studies of 4‐(1,2,3‐triazoyl)arylmethanone derivatives, 2022
- Mandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations, 2022
- New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors, 2022
- New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5- sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII, 2022
- Anti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles., 2022
- New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study, 2021
- Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis, 2021
- In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone, 2021
- Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors, 2020
- The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups, 2020
- Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors, 2020
- Evaluation of new 2-hydroxy-N-(4-oxo-2-substituted phenyl-1,3- thiazolidin-3-yl)-2-phenylacetamide derivatives as potential antimycobacterial agents, 2020
- Design and synthesis of novel peptidomimetics for cancer immunotherapy, 2020
- Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment, 2020
- Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies, 2020
- Novel Indole-Based Hydrazones as Potent Inhibitors of the alpha-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae, 2020
- Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors, 2019
- Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII, 2019
- Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies, 2019
- Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme, 2019
- Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold, 2019
- Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies, 2019
- Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors, 2018
- A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives, 2018
- Aromatase Inhibition by 2-methyl indole hydrAzone derivatives evaluated via molecular docking and in vitro activity studies, 2018
- Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms, 2017
- Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators, 2017
- Target Recognition Molecules and Molecular Modeling Studies, 2017
- Computer design synthesis and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis, 2017
- Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases, 2017
- Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis, 2017
- Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives, 2016
- A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome, 2016
- A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms, 2016
- Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes, 2016
- Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme, 2015
- Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action, 2015
- Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII, 2015
- New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies, 2015
- Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies, 2015
- Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid Synthesis biological evaluation and molecular modelling studies, 2014
- A Class of Sulfonamides with Strong Inhibitory Action against the alpha-Carbonic Anhydrase from Trypanosoma cruzi, 2013
- The extremo carbonic anhydrase CA from Sulfurihydrogenibium azorense the fastest CA known is highly activated by amino acids and amines, 2013
- o Benzenedisulfonimido sulfonamides are potent inhibitors of the tumor associated carbonic anhydrase isoforms CA IX and CA XII, 2013
- Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo, 2013
- Inhibition of tumor associated human carbonic anhydrase isozymes IX and XII by a new class of substituted phenylacetamido aromatic sulfonamides, 2013
- Structure based design synthesis and structure activity relationships of dibenzosuberyl and benzoate substituted tropines as ligands for acetylcholine binding protein, 2012
- Identification of novel 7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric 7 receptor ligand binding domain, 2012
- Fragment growing induces conformational changes in acetylcholine binding protein a structural and thermodynamic analysis, 2011
- Acetylcholine binding protein AChBP as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors, 2011
- Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis, 2009
- A G q 11 coupled mutant histamine H 1 receptor F435A activated solely by synthetic ligands RASSL, 2005
- Cytotoxic Effect of Novel 1-Ethyl and 2-Methyl Indole Derivatives on Breast Cancer Cells: ER and Aromatase as Their Potential Therapeutic Targets,
- Evaluation of Anti-inflammatory Effect of Novel Fingolimod Based Compound F1-12h in SH-SY5Y, SK-N-SH and U-118MG Cells for the Efficancy in Multiple Sclerosis, 2018
- Computer Aided Design and Synthesis of New Ursane Triterpenoids with Nuclear Factor Kappa B Inhibition Effect,
- Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Sentezi,
- Design and discovery of novel melatonin analogues as CYP1B1 inhibitors, 2017
- Inhibition of Canavalia ensiformis urease with new 1,2,4-triazole compounds,
- Eraslan Elma P., Akdemir A., Göktaş F., Karali N.L., Angeli A. , Kızılırmak M. , et al., ”Synthesis, biological evaluation and docking studies of structurally novel 1H-indole-2,3-dion 3-(N-phenylthiosemicarbazones) as potential hCA IX and XII inhibitors, 2017
- Structurally novel thiazolidinone-containing compounds that do not contain sulfonamide groups display antifungal activity, 2017
- Bazı Uvaol Türevlerinin Sentezi ve in vitro Biyokaitivitelerininİncelenmesi, 2017
- Design and discovery of novel melatonin analogues as CYP1B1 inhibitors, 2017
- Molecular modelling studies to guide synthesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA, 2017
- Structurally novel thiazolidinone-containing compounds that do not contain sulfonamide groups display antifungal activity, 2017
- Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Sent, 2017
- Molecular modelling studies to guide sythesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA, 2017
- Evaluation of Anti-inflammatory Effect of Novel Fingolimod Based Compound F1-12h in SH-SY5Y, SK-N-SH and U-118 MG Cells for the Efficacy in Multiple Sclerosis, 2017
- Flavonoids and Phenolics. Medicinal Chemistry Lessons From Nature, ISBN: 978-981-5079-10-4, 2022
- Medisinal Kimya Giriş, ISBN: 9786257146821, 2021
- Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications, ISBN: 9780444632586, 2015
- Pharmacology of nicotinic acetylcholine receptors from the basic and therapeutic perspectives, ISBN: , 2011
- Mosaic Research , 2004